§ PG.INDEX · 40 GRADED
Every peptide
we’ve graded.
Browse the complete Peptigrade index. Each entry shows the top-outcome grade, total studies indexed, and current regulatory status. Click any row to see the full evidence breakdown.
HCG
Human Chorionic Gonadotropin — 237-amino-acid α/β heterodimeric glycoprotein hormone (~36.7 kDa)
Ovulation induction in assisted reproductive technology (ART)
Strong
Reproductive & Endocrine
IGF-1
Insulin-like Growth Factor 1 — 70-amino-acid single-chain polypeptide (recombinant human mecasermin is the FDA-approved form; IGF-1 LR3 is a synthetic long-R3 analog with Arg3→Glu and a 13-residue N-terminal extension)
Severe primary IGF-1 deficiency (pediatric growth failure)
Strong
Growth & Metabolic
Methylene Blue
Methylthioninium chloride — 3,7-bis(dimethylamino)phenothiazin-5-ium chloride
Acquired methemoglobinemia (IV, prescription)
Strong
Cognitive & Mood
Oxytocin
Oxytocin — cyclic nonapeptide Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide Cys1-Cys6)
Labor induction & augmentation
Strong
Neuroendocrine & Social Cognition
Semaglutide
GLP-1 receptor agonist
Type 2 diabetes
Strong
Metabolic & Weight
Tesamorelin
Tesamorelin acetate — N-[(3E)-1-oxo-3-hexen-1-yl]-GHRH(1-44), a trans-3-hexenoyl-modified 44-amino-acid human GHRH analog
HIV-associated lipodystrophy — visceral fat reduction
Strong
Growth Hormone Axis
Tirzepatide
Dual GIP / GLP-1 receptor agonist
Obesity
Strong
Metabolic & Weight
Vitamin B-12
Cobalamin — cobalt-containing corrinoid cofactor (cyanocobalamin, methylcobalamin, hydroxocobalamin, adenosylcobalamin)
Treatment of pernicious anemia and B12-deficiency megaloblastic anemia
Strong
Nutraceutical
Cagrilintide
Cagrilintide — long-acting amylin analog (C20 fatty-acid–acylated, 37 aa)
Obesity (combined with semaglutide as CagriSema)
Promising
Metabolic & Weight
CJC-1295
CJC-1295 with Drug Affinity Complex — albumin-binding GHRH(1-29) analog, [D-Ala², Gln⁸, Ala¹⁵, Leu²⁷]-GHRH(1-29)-Lys³⁰-Nε-maleimidopropionyl
Sustained GH and IGF-1 elevation
Promising
Growth Hormone Axis
Glutathione
L-Glutathione (reduced) — γ-L-glutamyl-L-cysteinyl-glycine
Restoration of GSH and oxidative-stress biomarkers in deficient populations (oral precursor supplementation)
Promising
Endogenous antioxidant / detoxification
Ipamorelin
Selective growth hormone secretagogue
GH secretion
Promising
Growth Hormone Axis
Kisspeptin-10
Kisspeptin-10 (KP-10) — C-terminal decapeptide of metastin, H-YNWNSFGLRF-NH₂
Diagnostic GnRH/LH-axis testing in hypogonadotropic hypogonadism
Promising
Reproductive & Endocrine
NAD+
β-Nicotinamide adenine dinucleotide (oxidized form) — C21H27N7O14P2, MW 663.43 Da
Raising whole-blood / skeletal-muscle NAD+ with oral NR in deficient or older adults (biomarker endpoint)
Promising
Longevity & Aging
Ostarine (MK-2866)
Enobosarm — (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
Lean body mass in cancer cachexia and sarcopenic populations
Promising
SARM
PT-141
Bremelanotide
Hypoactive sexual desire disorder (HSDD)
Promising
Sexual Health
Sermorelin
Sermorelin acetate — GHRH(1-29)-NH₂, synthetic growth-hormone-releasing-hormone analog
Diagnostic provocation for pediatric growth hormone deficiency
Promising
Growth Hormone Axis
SS-31 (Elamipretide)
Elamipretide — Szeto-Schiller tetrapeptide D-Arg-Dmt-Lys-Phe-NH₂
Barth syndrome
Promising
Mitochondrial
Tesofensine
NS2330 — phenyltropane triple monoamine (NE/DA/5-HT) reuptake inhibitor
Obesity (BMI ≥30)
Promising
Metabolic & Weight
BPC-157
Body Protection Compound 157 — pentadecapeptide GEPPPGKPADDAGLV
Tendon healing
Mixed
Recovery & Repair
GHK-Cu
Copper tripeptide-1
Wound healing (topical)
Mixed
Recovery & Repair
Melanotan II
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 — cyclic heptapeptide α-MSH analog
Skin tanning / melanogenesis
Mixed
Pigmentation & Melanocortin
MK-677 (Ibutamoren)
Ibutamoren — orally-active non-peptide ghrelin/GHSR-1a agonist (spiroindoline small molecule, MW 528.67 free base)
GH / IGF-1 elevation (pharmacodynamic)
Mixed
Growth Hormone Axis
MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA Type-c — 16-aa peptide MRWQEMGYIFYPRKLR
Insulin sensitivity & metabolic homeostasis
Mixed
Metabolic & Longevity
RAD-140 (Testolone)
RAD-140 — 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile (Vosilasarm, EP0062)
AR+/ER+ metastatic breast cancer (monotherapy)
Mixed
SARM
Retatrutide
Triple GIP / GLP-1 / glucagon receptor agonist (LY3437943)
Obesity / chronic weight management
Mixed
Metabolic & Weight
Selank
Selank — heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin + C-terminal Pro-Gly-Pro)
Generalized anxiety disorder
Mixed
Anxiolytic & Nootropic
Semax
Heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro — synthetic analog of ACTH(4-7) with C-terminal Pro-Gly-Pro extension
Acute ischemic stroke (adjunctive treatment)
Mixed
Nootropic & Neuroprotective
SNAP-8
Acetyl Octapeptide-3 — Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
Fine-line / wrinkle depth reduction (topical)
Mixed
Cosmetic & Skin
TB-500
Thymosin β-4 (synthetic fragment)
Soft tissue repair
Mixed
Recovery & Repair
Thymalin
Thymalin — bovine thymus polypeptide complex (mixture of short immunomodulatory peptides including Glu-Trp (EW), Lys-Glu (KE), and EDP)
Adjunctive immunomodulation in severe COVID-19 in older adults
Mixed
Immune Modulation & Geroprotection
5-Amino-1MQ
5-Amino-1-methylquinolinium (small-molecule NNMT inhibitor)
Diet-induced obesity / body-weight reduction
Weak
Metabolic & Weight
AOD-9604
Anti-Obesity Drug 9604 — Tyr-hGH(177-191), a 16-amino-acid synthetic fragment of human growth hormone (sequence YLRIVQCRSVEGSCGF) with an N-terminal tyrosine addition and a Cys7-Cys14 intramolecular disulfide bond
Body weight / fat-mass reduction in adults with obesity
Weak
Growth Hormone Axis — Fragment
BAM15
N5,N6-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Diet-induced obesity / weight loss
Weak
Metabolic & Weight
DSIP
Delta Sleep-Inducing Peptide — nonapeptide WAGGDASGE
Sleep quality in chronic insomnia
Weak
Sleep & Stress
Epitalon
Epitalon — tetrapeptide Ala-Glu-Asp-Gly (AEDG)
Telomerase activation & telomere elongation (in vitro / ex vivo)
Weak
Longevity & Telomere
Fragment 176-191
Human growth hormone C-terminal fragment 176-191 (hGH 176-191) — sequence FLRIVQCRSVEGSCGF
Fat loss / lipolysis
Weak
Metabolic & Body Composition
Lipo-C
Lipotropic injection (MIC) — methionine + inositol + choline, typically with cyanocobalamin (B12) and variable B-complex (B1/B2/B5/B6)
Weight loss / fat loss
Weak
Metabolic & Weight
PEG-MGF
PEGylated Mechano Growth Factor — IGF-1Ec C-terminal E-domain peptide (YQPPSTNKNTKSQRRKGSTFEEHK) conjugated to polyethylene glycol
Satellite cell activation & muscle repair
Weak
Growth Factor
SLU-PP-332
(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide — synthetic pan-agonist of estrogen-related receptors ERRα/β/γ (MW 290.32 g/mol, C₁₈H₁₄N₂O₂)
Exercise capacity / endurance in humans
Weak
Metabolic & Weight